MedTrace Logo

Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.

NCT05001048 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14

Last updated 2022-10-31

No results posted yet for this study

Summary

This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.

Conditions

  • Vasodilation
  • Vasoconstriction

Interventions

DRUG

Phenylephrine Hydrochloride

Series of three incremental bolus injections to observe α1-adrenoreceptor mediated vasoconstriction.

OTHER

Cold Pressor Test

Standardized sympathetic stressor involving submersion of the hand in ice-cold water for 3-minutes, aiming to elicit endogenous neurotransmitter release and blood pressure increases.

OTHER

Isocapnic Acute Hypoxia

During low altitude assessment, participants will be exposed to isocapnic hypoxia equivalent to 3,800m to assess responses to acute exposure.

OTHER

Hyperoxia

During high altitude assessments, participants will breathe an oxygen concentration comparable to their end-tidal values at low altitude for the assessment of the influences of acclimatization.

Sponsors & Collaborators

  • University of Alberta

    lead OTHER

Principal Investigators

  • Sean van Diepen, MD, MSc · University of Alberta

  • Craig Steinback, PhD · University of Alberta

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-08-04
Primary Completion
2021-12-07
Completion
2022-09-09

Countries

  • Canada

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05001048 on ClinicalTrials.gov