Peripheral Chemoreflex/Arterial Baroreflex Interaction in Patients With Electrical Carotid Sinus Stimulation

Summary

Peripheral chemoreceptors and baroreceptors are located in close proximity in the carotid artery wall at the level of the carotid bifurcation. Baroreceptor stimulation lowers sympathetic activity and blood pressure. In contrast, chemoreceptor stimulation raises sympathetic activity and blood pressure. Thus, beneficial effects of electrical carotid sinus stimulation on blood pressure could be diminished by chemoreceptor overactivity and/or concomitant chemoreceptor activation through the device. Therefore, our study will assess baroreflex/chemoreflex interactions in patients with resistant hypertension equipped with carotid sinus stimulators. The study will inform us of potential additional anti-hypertensive benefits of simultaneous chemoreceptor denervation during electrode placement. Furthermore, the results may provide information about suitable electrode design to spare co-activation of peripheral chemoreceptors. Taken together, the study will help develop strategies for improving responder rate and efficacy of carotid sinus stimulators in patients with resistant hypertension.

Conditions

• Hypertension, Resistant to Conventional Therapy

Interventions

OTHER

Hyperoxia without dopamine

Nearly complete hemoglobin oxygen saturation.

OTHER

Hyperoxia with dopamine

Nearly complete hemoglobin oxygen saturation. Dopamine dose 3 µg/kg/min.

OTHER

Hypoxia without dopamine

Target hemoglobin oxygen saturation (SpO2) 80%.

OTHER

Hypoxia with dopamine

Target hemoglobin oxygen saturation (SpO2) 80%. Dopamine dose 3 µg/kg/min.

Sponsors & Collaborators

• Charite University, Berlin, Germany

  collaborator OTHER

• Vanderbilt University School of Medicine

  collaborator OTHER

• Mayo Clinic

  collaborator OTHER

• University of Bristol

  collaborator OTHER

• Hannover Medical School

  lead OTHER

Principal Investigators

• Jens Tank, MD · Hannover Medical School

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-11-30

Primary Completion

2017-12-31

Completion

2017-12-31

Countries

• Germany

Study Locations