Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients

Summary

To test the effects of a 2- to 3-year intervention of the MIND diet versus usual post-stroke care on cognitive decline, the characteristic feature of dementia, and on brain biomarkers of Alzheimer's Disease (AD) and vascular disease in a Phase Ill randomized controlled trial of 250 patients hospitalized for acute ischemic stroke, aged 55 years or older, and without dementia who are discharged home following hospitalization.

Conditions

• Cognitive Decline
• Dementia, Vascular
• Alzheimer Disease
• Dementia
• Stroke

Interventions

OTHER

Behavioral Dietary intervention ( MIND Diet)

The MIND diet is a hybrid of the Mediterranean and DASH diets but with selected modifications based on the most compelling evidence in the diet dementia field. The MIND diet has the same basic components of the DASH and Mediterranean diets, such as emphasis on natural plant based foods and limited animal and high saturated fat foods, but uniquely specifies green leafy vegetables and berries as well as food component servings that reflect the nutrition dementia evidence.

OTHER

Behavioral Usual Care Diet Intervention

The Usual Care diet is comprised of both westernized (e.g. Steak, Mac n Cheese) and healthy ( veggie chili) food components

Sponsors & Collaborators

• University of Chicago

  collaborator OTHER

• Advocate Hospital System

  collaborator OTHER

• National Institute on Aging (NIA)

  collaborator NIH

• Rush University Medical Center

  lead OTHER

Principal Investigators

• Neelum T Aggarwal, MD. · Rush University Medical Center

• Christy Tangney, PhD · Rush University Medical Center

Study Design

Allocation

NA

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

55 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-12-14

Primary Completion

2026-07-31

Completion

2026-07-31

Countries

• United States

Study Locations