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Methionine Requirements During Healthy Human Pregnancy

NCT04326322 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 69

Last updated 2026-02-12

No results posted yet for this study

Summary

The current recommendations for dietary amino acid intake in pregnant women are based on calculations from requirements of adult men. The study aims to determine methionine requirements during early (11-20 weeks) and late (31-38 weeks) stages of pregnancy. Methionine, an essential amino acid (building block of body protein), is necessary for protein synthesis and for DNA related cellular functions. A non-invasive, novel method based on different diets, stable isotopes (the safe kind) and simple breath collection will be used. This method has recently been used by our laboratory to study other amino acids during pregnancy.

Conditions

  • Pregnancy Related

Interventions

DIETARY_SUPPLEMENT

Methionine Intake

Intakes will be randomly chosen from a list of 7 doses of methionine. Each intake will will be repeated approximately 5 times.

Sponsors & Collaborators

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Rajavel Elango, PhD · University of British Columbia

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
20 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-09-14
Primary Completion
2023-06-21
Completion
2024-06-01

Countries

  • Canada

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04326322 on ClinicalTrials.gov