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Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis

NCT04320264 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-08-07

No results posted yet for this study

Summary

The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.

Conditions

  • Metabolic Inflexibility

Interventions

PROCEDURE

Weight loss surgery

Severely obese women (BMI \>40) undergo sleeve gastrectomy

Sponsors & Collaborators

  • Duke University

    collaborator OTHER

  • University of Arkansas

    collaborator OTHER

  • East Carolina University

    lead OTHER

Principal Investigators

  • Joseph Houmard, PhD · East Carolina University

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-03-03
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04320264 on ClinicalTrials.gov