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Metabolomics Study on Postoperative Intensive Care Acquired Muscle Weakness

NCT03810768 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 20

Last updated 2026-03-03

No results posted yet for this study

Summary

In this mono-center pilot trial, surgical patients who are at high risk to be admitted to intensive care will be screened and asked for participation. We are going to take blood and muscle samples at respecified time points to do metabolic, histological and molecular testing.

Aim of the study is to investigate (1) changes of the blood metabolome in patients with ICUAW (intensive care unit acquired weakness) and (2) identify metabolic components who are responsible for ICUAW or can be used as marker for ICUAW.

Conditions

  • Metabolomics
  • Critical Care
  • Critical Illness
  • Critical Illness Myopathy
  • Critical Illness Polyneuropathy
  • Intensive Care (ICU) Myopathy
  • Muscle Weakness

Sponsors & Collaborators

  • Helmholtz Zentrum München

    collaborator INDUSTRY

  • Charite University, Berlin, Germany

    collaborator OTHER

  • Medical University of Vienna

    collaborator OTHER

  • Technical University of Munich

    lead OTHER

Principal Investigators

  • Stefan J Schaller, MD · Technical University of Munich

  • Hennig Wackerhage, PhD · Technical University of Munich

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-09-02
Primary Completion
2026-11-01
Completion
2026-12-31

Countries

  • Austria
  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03810768 on ClinicalTrials.gov