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Abdominal Adiposity and Muscle Mitochondrial Functions

NCT00446745 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2012-09-19

No results posted yet for this study

Summary

Numerous studies have demonstrated that excess perivisceral adipose tissue is associated with metabolic diseases such as insulin resistance.

In skeletal muscle, insulin resistance has been correlated with reduced mitochondrial oxidative functions. According to the actual theory, mitochondrial dysfunctions are proposed to play a causal role in the aetiology of insulin resistance. Mechanisms involve increased intramyocellular lipids storage. Yet, the causes responsible for the decline in muscle mitochondrial functions remain to be elucidated.

The investigators hypothesize that these alterations are induced by combined changes in plasma profiles of lipids and adipokines, which originate from perivisceral adipose tissue. The study aims at answering the following questions :

* Are muscle mitochondrial functions altered in association with increased perivisceral adipose tissue storage?
* Do changes in the pattern of plasma lipids and adipokines explain this correlation?

Conditions

  • Mitochondrial Respiratory Chain Deficiencies

Sponsors & Collaborators

  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

    lead OTHER

Principal Investigators

  • Yves Boirie, PU-PH · UMR1019 INRA - Auvergne University

  • Beatrice Morio, PhD · UMR 1019 INRA - Auvergne University

Eligibility

Min Age
35 Years
Max Age
50 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2006-04-30
Primary Completion
2006-12-31
Completion
2007-01-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00446745 on ClinicalTrials.gov