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Antibiotic Prophylaxis in High-Risk Arthroplasty Patients

NCT04297592 · Status: ENROLLING_BY_INVITATION · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 4618

Last updated 2025-07-03

No results posted yet for this study

Summary

To determine the effectiveness of a 7-day course of an oral, prophylactic antibiotic on the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk patient population.

Conditions

  • Infections Joint Prosthetic
  • Overweight or Obesity
  • MSSA Colonization
  • MRSA
  • Chronic Kidney Diseases
  • Diabetes
  • Autoimmune Diseases
  • Inflammatory Disease
  • Tobacco Use

Interventions

DRUG

Cephalexin

500 mg oral tablet, 4 times daily for 7 days

DRUG

Doxycycline

100 mg oral tablet, 2 times daily for 7 days

DRUG

Cefadroxil

500 mg oral tablet, 2 times daily for 7 days

Sponsors & Collaborators

Principal Investigators

  • Nicholas Bedard, MD · Mayo Clinic

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-06-11
Primary Completion
2026-06-30
Completion
2026-06-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04297592 on ClinicalTrials.gov