Rifampicin Combination Therapy Versus Monotherapy for Staphylococcal Prosthetic Joint Infection
NCT06172010 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 316
Last updated 2023-12-15
Summary
In this Dutch multicenter clinical trial, patients with a staphylococcal prosthetic joint infection, will, in the oral antibiotic treatment phase, be randomized between clindamycin monotherapy and rifampicin / levofloxacin combination therapy. The clinical endpoint will be treatment success one year after finishing antimicrobial treatment.
Conditions
- Prosthetic-joint Infection
- Infection Hip
- Infection; Knee, Joint
Interventions
- DRUG
-
Clindamycin
antimicrobial treatment in oral treatment phase of staphylococcal prosthetic joint infection
- DRUG
-
Rifampicin and levofloxacin
antimicrobial treatment in oral treatment phase of staphylococcal prosthetic joint infection
Sponsors & Collaborators
-
University Medical Center Groningen
collaborator OTHER -
Onze Lieve Vrouwe Gasthuis
collaborator OTHER -
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
collaborator OTHER -
Frisius Medisch Centrum
collaborator OTHER -
Isala
collaborator OTHER -
Martini Hospital Groningen
collaborator OTHER -
Radboud University Medical Center
collaborator OTHER -
Sint Maartenskliniek
collaborator OTHER -
Elisabeth-TweeSteden Ziekenhuis
collaborator OTHER - collaborator OTHER
-
Alrijne Hospital
collaborator OTHER -
Spaarne Gasthuis
collaborator OTHER -
Reinier Haga Orthopedisch Centrum
collaborator OTHER -
Tergooi Hospital
collaborator OTHER -
Rijnstate Hospital
collaborator OTHER -
Leiden University Medical Center
lead OTHER
Principal Investigators
-
Henk Scheper, MD · LUMC
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-04-01
- Primary Completion
- 2027-03-31
- Completion
- 2028-03-31
Countries
- Netherlands
Study Locations
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