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Knee Prosthetic Joint Infection Antibiotic Elution

NCT06023238 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2026-02-05

No results posted yet for this study

Summary

Patients presenting with prosthetic joint infections of a total knee replacement who are treated with an antibiotic spacer will be observed prospectively for their response to treatment and antibiotic elution profiles will be measured post-operatively utilizing mass spectrometry from synovial fluid acquired as part of standard of care in the management of prosthetic joint infection. Secondary outcomes including post-operative complications, re-operation rates, and re-admission rates will also be compared.

Conditions

  • Prosthetic-joint Infection
  • Arthroplasty Complications

Interventions

PROCEDURE

Treatment of Chronic TKA PJI

Patients will all undergo standard of care treatment for a chronic total knee arthroplasty prosthetic joint infection.

Sponsors & Collaborators

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Johannes F Plate, MD, PhD · University of Pittsburgh Medical Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-01-05
Primary Completion
2027-12-31
Completion
2029-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06023238 on ClinicalTrials.gov