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Personalized Swiss Sepsis Study

NCT04130789 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 17500

Last updated 2025-03-05

No results posted yet for this study

Summary

This multi-center study is to focus on patients with sepsis in Intensive Care Units (ICUs) in order to better understand the complex host-pathogen interaction and clinical heterogeneity associated with sepsis. Understanding this heterogeneity may allow the development of novel diagnostic approaches. Data from patients will be analyzed using state-of-the art analytical algorithms for biomarker discovery including machine learning and multidimensional mathematical modelling to explore the large datasets generated. In order to discover digital biomarkers for the study endpoints a case-control study design will be used to compare data patterns from patients with sepsis (cases) and those without sepsis (controls).

Conditions

Interventions

OTHER

compare data patterns by data-driven algorithms to determine sepsis

compare data patterns by data-driven algorithms including machine learning and multi-dimensional modelling to reliably determine sepsis

OTHER

compare data patterns by data-driven algorithms to predict sepsis-related mortality

compare data patterns by data-driven algorithms including machine learning and multi-dimensional modelling to to predict sepsis-related mortality

Sponsors & Collaborators

  • Swiss Personalized Health Network (SPHN)

    collaborator UNKNOWN

  • Personalized Health and Related Technologies (PHRT) initiative of ETH Zürich

    collaborator UNKNOWN

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Adrian Egli, PD Dr. · Clinical Microbiology, University Hospital Basel

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-11-15
Primary Completion
2022-05-31
Completion
2025-12-31

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04130789 on ClinicalTrials.gov