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microRNA 155 Levels and Periodontal Microflora (Bacteria and Virus) in Preeclampsia.

NCT04277390 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 445

Last updated 2020-02-25

No results posted yet for this study

Summary

Preeclamptic women with and without chronic periodontitis were recruited for the study. Subgingival plaque samples and placental tissue samples(postpartum) were obtained from the participants for the microbial analysis(bacteria, viruses) and MIR155 levels and comparison was done among groups. this study was designed in order to evaluate the role of periodontal microorganisms in preeclampsia and to find compare the MIR155 levels among participants, so as to check its importance as a biomarker for inflammatory disease like preeclampsia.

Conditions

Interventions

OTHER

clinical intervention for microbial analysis and MIR155 as biomarker

Subgingival plaque was collected with sterile curette and placental tissue sample(postpartum with surgical blade with the help of gynecologist. all the samples were subjected to RTPCR for analysis of microorganisms likeTannerella forsythia(Tf), Treponema denticola(Td), Porphyromonas gingivalis(Pg), Prevotella intermedia(Pi), Fusobacterium nucleatum(Fn). Herpes Simplex Virus(HSV), Ebstein Barr Virus(EBV), Human Cytomegalovirus(HCMV). and MIR155 levels were also estimated

Sponsors & Collaborators

  • Meenakshi Ammal Dental College and Hospital

    lead OTHER

Principal Investigators

  • Jaideep Mahendra, MDS, PhD · Meenakshi Ammal Dental College

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-08-01
Primary Completion
2018-08-20
Completion
2019-11-10

Countries

  • India

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04277390 on ClinicalTrials.gov