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Influence of Osmotic Stimulation of Vasopressin on Autonomic Function

NCT04233606 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2023-11-13

No results posted yet for this study

Summary

The regulation of total body water that defines human hydration status is a complex and dynamic process. Current methods of assessing hydration status (e.g. hematologic and urinary analyses) lack the ability to track changes in hydration status in real-time due to whole-body homeostatic physiologic processes required to maintain central pressure and cardiovascular function. This project will address this problem by assessing the relationship between autonomic function (measured using heart rate variability), a brain-derived process that regulates cardiovascular function, and changes in the hydration-mediated hormone vasopressin.

Conditions

  • Water Stress
  • Body Water Dehydration

Interventions

OTHER

Hypertonic Saline

Infusion of hypertonic saline to induce an osmotic secretion of the hormone vasopressin

OTHER

Normal Saline

Infusion of normal saline to inhibit the secretion of the hormone vasopressin

Sponsors & Collaborators

  • University of North Carolina, Greensboro

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-11-30
Primary Completion
2024-07-31
Completion
2024-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04233606 on ClinicalTrials.gov