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Weaning Approaches for Vasopressin in Sepsis

NCT07067866 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 82

Last updated 2026-01-02

No results posted yet for this study

Summary

In this study, we aim to evaluate the incidence of hypotension during vasopressin weaning by comparing two methods - titrated reduction versus abrupt withdrawal - through the conduct of a randomized clinical trial.

Conditions

  • Septic Shock

Interventions

OTHER

Titrated weaning of vasopressin.

The titrated group will follow the vasopressin weaning protocol used in the DOVSS study (reduction of 0.01 U/min per hour).

OTHER

Abrupt weaning of vasopressin.

The abrupt group will discontinue the vasopressin infusion at the time of randomization, without dose titration.

Sponsors & Collaborators

  • Hospital Nossa Senhora da Conceicao

    lead OTHER

Principal Investigators

  • Cássio Mallmann, Critical Care Physician, MS · Hospital Nossa Senhora da Conceicao

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-10-01
Primary Completion
2027-12-31
Completion
2028-10-01

Countries

  • Brazil

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07067866 on ClinicalTrials.gov