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Walking the Isobole of Drug Interaction

NCT02067936 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 87

Last updated 2015-12-04

No results posted yet for this study

Summary

The investigators study whether four equipotent combinations of propofol and remifentanil (as predicted by interaction models for "tolerance of laryngoscopy") result in identical haemodynamic conditions, independent of their relative different balance between the concentration of propofol and remifentanil.

Conditions

  • Hemodynamic Instability
  • Disorder of Oxygen Transport
  • Interaction
  • Anesthesia

Interventions

DRUG

Group A propofol + remifentanil

Predicted TOL90% according to Bouillon model

DRUG

Group B propofol + remifentanil

TOL 90% according to the Bouillon interaction model

DRUG

Group C propofol + remifentanil

TOL 90% according to the Bouillon interaction model

DRUG

group D propofol + remifentanil

TOL 90% according to the Bouillon interaction model

Sponsors & Collaborators

  • University Medical Center Groningen

    lead OTHER

Principal Investigators

  • Hugo EM Vereecke, MD, PhD · University Hospital Medical center, university of groningen

Study Design

Allocation
RANDOMIZED
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-02-28
Primary Completion
2015-09-30
Completion
2015-09-30

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02067936 on ClinicalTrials.gov