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Efficacy of Ketamine-Propofol for Short Surgical Procedures

NCT01651988 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 77

Last updated 2012-07-27

No results posted yet for this study

Summary

OBJECTIVE: To determine the efficacy of ketamine-propofol anesthesia in a mixture 1:2 (1 mg of ketamine per 2 mg of propofol) for short minimally invasive surgical procedures.

METHODS: The investigators performed a prospective study through randomization of 77 patients undergoing short surgical procedures in two study groups: one received a mixture of ketamine-propofol in a 1:1 ratio, and the other received a 1:2 mixture. Data were stored in an Excel spreadsheet and analyzed using the statistical program Epi-Info (TM) 3.5.3. The investigators performed the comparison of qualitative and quantitative variables.

KEY WORDS: ketamine, propofol, anesthesia.

Conditions

  • Anesthesia; Reaction

Interventions

DRUG

Ketamina-Propofol Combination

After randomization to the study group, the patients were given: Procedures \< 10 minutes 1. Ketamine-Propofol Combination KETOFOL 1:1 * Propofol: 0.2 cc/kg (10 mg/cc = 2 mg/kg) * Ketamine: cc/kg 0.04 (50 mg/cc = 2 mg/kg) * Simple 1% lidocaine: 0,1 cc/kg (10 mg/cc = 1 mg/kg) 2. Ketamine-Propofol Combination KETOFOL 1:2 * Propofol: 0.2 cc/kg (10 mg/cc = 2 mg/kg) * Ketamine: 0.02 cc/kg (50 mg/cc = 1 mg/kg) * Simple 1% lidocaine: 0,1 cc/kg (10 mg/cc = 1 mg/kg) Procedures \> 10 minutes In addition to the initial bolus, an infusion was started: KETOFOL 1:1 20 cc of propofol (10 mg/cc = 200 mg in total) 4 cc of ketamine (50 mg/cc = 200 mg in total) 10cc lidocaine 1% simple (10 mg/cc = 100 mg in total) 66 cc 0.9% SSN KETOFOL 1:2 20 cc of propofol (10 mg/cc = 200 mg in total) 2 cc of ketamine (50 mg/cc = 100 mg in total) 10cc lidocaine 1% simple (10 mg/cc = 100 mg in total) 68 cc 0.9% SSN Speed infusion: 0,03cc/kg/min

Sponsors & Collaborators

  • Universidad de Cartagena

    lead OTHER

Principal Investigators

  • Ricardo Poveda, Resident · University of Cartagena

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2011-03-31
Primary Completion
2011-09-30
Completion
2011-09-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01651988 on ClinicalTrials.gov