Multi-center Clinical Study of Cord Blood Stem Cell Transplantation for IBD Caused by IL-10R Gene Deficiency

Summary

Very early onset inflammatory bowel disease (VEO-IBD) is a special subtype of children's inflammatory bowel disease (IBD). VEO-IBD is mostly caused by single-gene defects and can be cured by allo-hematopoietic stem cell transplantation ( HSCT). Umbilical Cord Blood Transplantation (UCBT) is less reported in these patients.

Conditions

• Inflammatory Bowel Diseases

Interventions

PROCEDURE

Cord Blood Stem Cell Transplantation

Unrelated cord blood stem cell selection; Reduced intensity conditioning regime; GVHD prevention; Infection prevention.

Sponsors & Collaborators

• Shanghai Children's Hospital

  collaborator OTHER

• Children's Hospital of Soochow University

  collaborator OTHER

• Beijing Children's Hospital

  collaborator OTHER

• Guangzhou Women and Children's Medical Center

  collaborator OTHER

• Shenzhen Children's Hospital

  collaborator OTHER_GOV

• Wuhan Women and Children's Medical Center

  collaborator OTHER

• Children's Hospital of Nanjing Medical University

  collaborator OTHER

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Children's Hospital of Fudan University

  lead OTHER

Principal Investigators

• Jiang Hui, Master · Shanghai Children's Hospital

• Hu Shaoyan, PHD · Children's Hospital of Soochow University

• Qin Maoquan, PHD · Beijing Children's Hospital

• Jiang Hua, PHD · Guangzhou Women and Children's Medical Center

• Liu Sixi, Master · Shenzhen Children's Hospital

• Xiong Hao, PHD · Wuhan Women and Children's Medical Center

• Fang Yongjun, PHD · Children's Hospital of Nanjing Medical University

• Wang Dao, PHD · The First Affiliated Hospital of Zhengzhou University

Eligibility

Min Age

1 Month

Max Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-12-01

Primary Completion

2022-10-31

Completion

2023-10-31

Countries

• China

Study Locations