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Alterations in Intestinal Microbiota, Metabolites, and Immune Cells in Allo-HSCT

NCT06143501 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 250

Last updated 2023-11-22

No results posted yet for this study

Summary

This research project delves into the critical role of gut immunity in the occurrence and progression of acute graft-versus-host disease (aGVHD) post allogeneic hematopoietic stem cell transplantation (allo-HSCT). Addressing the current gaps in understanding the involvement of intestinal microbiota, metabolites, and cellular metabolism in clinical aGVHD, the study involves comprehensive analyses on 200 allo-HSCT patients and 50 healthy volunteers. By scrutinizing changes in gut microbiota, metabolites, and immune cell metabolism, the research aims to shed light on their roles in allo-HSCT and their correlation with post-transplant complications. The findings are poised to offer crucial insights for diagnosing and prognosticating complications following transplantation.

Conditions

  • Graft Vs Host Disease

Interventions

DIAGNOSTIC_TEST

Blood Sample

6 ml blood (collection occurs once pre-transplantation and at three designated follow-up time points post-transplantation)

DIAGNOSTIC_TEST

Stool Sample

pea-sized amount (collection occurs once pre-transplantation and at three designated follow-up time points post-transplantation)

DIAGNOSTIC_TEST

Urine Sample

8 ml (collection occurs once pre-transplantation and at three designated follow-up time points post-transplantation)

Sponsors & Collaborators

  • The First Affiliated Hospital of Soochow University

    lead OTHER

Principal Investigators

  • Yang Xu, M.D · The First Affiliated Hospital of Soochow University

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-09-01
Primary Completion
2024-12-31
Completion
2024-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06143501 on ClinicalTrials.gov