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Ontogeny of MAIT Cells in Neonates and Hematopoietic Stem Cell Transplant Recipients

NCT02403089 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2023-02-03

No results posted yet for this study

Summary

The objective of this study is 1/ to determine the rate and kinetics of MAIT cell expansion and maturation in neonates in relation with gestational age, and in HSCT recipient children in relation with the source of donor stem cells, 2/ to correlate gut microbiota diversity and function with MAIT cell maturation and function in neonates and HSCT recipients; and 3/ to link MAIT cells and gut microbiota composition with microbial infections and severe intestinal inflammatory events in term and preterm neonates, and in HSCT recipients

Conditions

  • Term and Preterm Neonates (24-41 Weeks Gestational Age)
  • Hematopoietic Stem Cell Transplant Recipient Children

Interventions

OTHER

Tubes fund recovery blood count

Tubes fund recovery of blood counts among newborns

OTHER

the rest of the blood test and stool sample

blood samples on the recovery kinetics after transplant. The rest of the blood test and stool sample done as part of a routine examination.

Sponsors & Collaborators

  • Institut National de la Santé Et de la Recherche Médicale, France

    collaborator OTHER_GOV

  • Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

    collaborator OTHER

  • Institut Curie

    collaborator OTHER

  • Assistance Publique - Hôpitaux de Paris

    lead OTHER

Principal Investigators

  • Biran Valérie, PHD · Assistance Publique - Hôpitaux de Paris

Eligibility

Min Age
1 Day
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-03-31
Primary Completion
2018-02-28
Completion
2018-02-28

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02403089 on ClinicalTrials.gov