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Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant Disorders

NCT00744692 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 22

Last updated 2014-08-13

Study results available
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Summary

The primary objective is to determine the feasibility of attaining acceptable rates of donor cell engraftment (\>25% donor chimerism at 180 days) following reduced intensity conditioning (RIC) regimens in pediatric patients \< 21 years receiving cord blood transplantation for non-malignant disorders.

Conditions

  • Non Malignant Disorders
  • Immunodeficiencies
  • Congenital Marrow Failures
  • Hemoglobinopathies
  • Inborn Errors of Metabolism
  • Sickle Cell
  • Thalassemia
  • Lysosomal Storage Disease

Interventions

BIOLOGICAL

Unrelated Umbilical Cord Blood Transplant

Reduced Intensity Conditioning for unrelated umbilical cord blood transplant

DRUG

Reduced Intensity Conditioning

Sponsors & Collaborators

Principal Investigators

  • Suhag Parikh, MD · Duke Pediatric Blood and Marrow Transplant

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Max Age
21 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-10-31
Primary Completion
2012-12-31
Completion
2014-04-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00744692 on ClinicalTrials.gov