Multi-center Clinical Study of Cord Blood Stem Cell Transplantation for SCID

Summary

Severe combined immunodeficiency (SCID) is a rare disease caused by a group of genetic disorders that leads to early death from recurrent infections in affected children.The only curative therapy for SCID is allogeneic hematopoietic stem cell transplantation.Unrelated umbilical cord blood(UCB) is increasingly used as an alternative to bone marrow.

Conditions

• Severe Combined Immunodeficiency Disease

Interventions

PROCEDURE

cord blood stem cell transplantation

Unrelated cord blood stem cell selection； Reduced intensity conditioning； GVHD prevention； Infection prevention.

Sponsors & Collaborators

• Shanghai Children's Hospital

  collaborator OTHER

• Children's Hospital of Soochow University

  collaborator OTHER

• Beijing Children's Hospital

  collaborator OTHER

• Guangzhou Women and Children's Medical Center

  collaborator OTHER

• Shenzhen Children's Hospital

  collaborator OTHER_GOV

• Wuhan Women and Children's Medical Center

  collaborator OTHER

• Children's Hospital of Nanjing Medical University

  collaborator OTHER

• The First Affiliated Hospital of Zhengzhou University

  collaborator OTHER

• Children's Hospital of Fudan University

  lead OTHER

Principal Investigators

• jiang hui, master · Shanghai Children's Hospital

• hu shaoyan, PhD · Children's Hospital of Soochow University

• qin maoquan, master · Beijing Children's Hospital

• jiang hua, PhD · Guangzhou Women and Children's Medical Center

• liu sixi, master · Shenzhen Children's Hospital

• xiong hao, PhD · Wuhan Women and Children's Medical Center

• fang yongjun, PhD · Children's Hospital of Nanjing Medical University

• wang dao, PhD · The First Affiliated Hospital of Zhengzhou University

Eligibility

Min Age

1 Month

Max Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-12-01

Primary Completion

2022-10-31

Completion

2023-10-31

Countries

• China

Study Locations