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Non-invasive Aortic Aneurysm Tissue Characterization Using Wall Viscoelasticity

NCT04150653 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2023-03-10

No results posted yet for this study

Summary

Abdominal aortic aneurysm (AAA) is an abnormal dilatation of the aorta in the abdomen due to a wall weakening caused by atherosclerosis. While indications for a rupture intervention are based on AAA maximal diameter (MaxD) (5 cm), 23% of ruptured AAAs are less than 5 cm and in large AAAs, rupture rate could be lower than expected. We propose to expand and validate our vascular ultrasound elastography software to 3D. Strain maps generated from radiofrequency (RF) data acquired from 30 AAA patients with a matrix-array 3D probe will be registered to conventional CT (phase 1) and validated to a biomechanical for characterization of AAA wall, assessing vulnerability and influence of surrounding tissues (phase 2). At the end of the project, we will have analyzed 3D strain maps to improve patient selection before surgery.

Conditions

  • Abdominal Aortic Aneurysm Without Rupture

Interventions

DEVICE

Multiphase scan CT, non-invasive vascular ultrasound elastography by ultrasound (NIVE)

Multiphase scan CT, non-invasive vascular ultrasound elastography by ultrasound (NIVE)

Sponsors & Collaborators

  • McGill University

    collaborator OTHER

  • University of Calgary

    collaborator OTHER

  • Eindhoven University of Technology

    collaborator OTHER

  • Centre hospitalier de l'Université de Montréal (CHUM)

    lead OTHER

Principal Investigators

  • Samuel Kadoury, PhD · Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM) and Polytechnique Montréal

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-09-01
Primary Completion
2023-12-31
Completion
2024-12-31

Countries

  • Canada

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04150653 on ClinicalTrials.gov