Non-Invasive Quantitative Imaging of Human Local Arterial Wall Elasticity Using Supersonic Shear Imaging

Summary

Arterial stiffness is associated with increased risk of cardiovascular events and death.

Most of existing technique need dedicated device for arterial stiffness evaluation and indirect calculation of intra arterial pressure. Supersonic Shear Imaging (SSI) is a novel non-invasive technique based on remote palpation of biological tissues that can image with very high temporal resolution (up to 10,000 images/s) and quantify the local viscoelastic properties of tissues. The investigators goal was to apply this SSI technique for arterial stiffness evaluation and local pulse wave velocity (PWV) calculation.

As a first step, the primary goal of this study is to establish normal values of local pulse wave velocity and arterial stiffness (carotid and femoral) by SSI on hundred healthy volunteers.

Conditions

• Healthy Volunteers
• Vascular Ehlers Danlos Syndrome

Interventions

OTHER

SSI and SphygmoCor® evaluations

* SSI evaluation need Aixplorer vascular ultrasound machine (available in our department) with 8 MHz linear array probe applied on the carotid and femoral artery. * SphygmoCor® evaluation used pressure captors on carotid and femoral sites to record the intra-arterial pressure wave time delay after QRS wave. After distance calculation between the two sites, Aortic PWV can be derived.

Sponsors & Collaborators

• National Research Agency, France

  collaborator OTHER

• SOCIETE FRANCAISE DE MEDECINE VASCULAIRE

  collaborator UNKNOWN

• French Cardiology Society

  lead OTHER

Principal Investigators

• Emmanuel Messas, MD · Hôpital Européen Georges-Pompidou

• Anne Blanchard, MD · Hôpital Européen Georges-Pompidou

• Joseph Emmerich, MD, PhD · Hôpital Européen Georges-Pompidou

• Xavier Jeunemaitre, MD, PhD · Hôpital Européen Georges-Pompidou

• Michael Franck, MD · Hôpital Européen Georges-Pompidou

• Olivier Steinchen, MD · Hôpital Européen Georges-Pompidou

• Michel Azizi, MD, PhD · Hôpital Européen Georges-Pompidou

Study Design

Allocation

NON_RANDOMIZED

Masking

NONE

Model

FACTORIAL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2010-03-31

Primary Completion

2011-03-31

Completion

2011-03-31

Countries

• France

Study Locations