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Effect of Weight Loss Surgery on Stem Cells.

NCT04132531 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 38

Last updated 2019-10-18

No results posted yet for this study

Summary

Obesity and diabetes are linked to increased risk for health problems such as heart attack, stroke, and death. At the cellular level, obesity and diabetes increase levels of harmful inflammatory cells (M1 macrophages) and decreases levels of protective stem cells (circulating progenitor cells) in the blood.

Bariatric (weight loss) surgery is an effective treatment that leads to significant weight loss and improved health in patients with obesity. However, it is unknown if weight loss surgery also replenishes healthy stem cells and decreases inflammatory cells in the body. Therefore, the purpose of this research study is to compare levels of these stem and inflammatory cells before and after bariatric surgery, and to compare to a control group of healthy normal weight participants.

The investigators anticipate that inflammatory cell levels will be reduced and stem cell levels and function will be restored after bariatric surgery, similar to levels of healthy normal weight individuals.

Conditions

  • Obesity, Morbid
  • Stem Cells
  • Cardiovascular Morbidity

Interventions

PROCEDURE

Bariatric (weight loss) surgery

Surgical intervention for weight reduction, whereby the stomach is resected and the gastrointestinal tract is rerouted in the case of Roux-en-y gastric bypass, or the stomach is only resected in the case of sleeve gastrectomy.

Sponsors & Collaborators

  • Humber River Hospital

    collaborator OTHER

  • University of Western Ontario, Canada

    collaborator OTHER

  • Unity Health Toronto

    lead OTHER

Principal Investigators

  • Subodh Verma, MD · Unity Health Toronto

  • David A Hess, PhD · Robart's Research Institute, London, Ontario

Eligibility

Min Age
19 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-05-01
Primary Completion
2019-06-25
Completion
2019-08-13

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04132531 on ClinicalTrials.gov