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Modulation of the Inflammatory Response in Bariatric Surgery

NCT06915558 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2025-04-08

No results posted yet for this study

Summary

This study will evaluate how different anesthesia techniques affect inflammation after bariatric surgery. Patients will be randomly assigned to receive one of three approaches: opioid-free anesthesia, intravenous anesthesia with opioids, or inhalational anesthesia with opioids.

The study will measure blood levels of inflammation-related substances (such as IL-6, CRP, cortisol, ESR , WBC and lactate) at several time points before and after surgery. Heart rate variability will also be monitored as an indicator of the body's stress response.

The results may help identify anesthesia strategies that reduce inflammation and improve recovery in patients undergoing bariatric surgery.

Conditions

  • Obesity
  • Bariatric Surgery Candidate
  • Inflammation
  • Postoperative Pain
  • Opioid-Free Anesthesia
  • Heart Rate Variability

Interventions

PROCEDURE

Opioid-Free Anesthesia (OFA)

Opioid-free anesthesia using a multimodal approach, including dexmedetomidine, lidocaine, ketamine, and magnesium sulfate. No intraoperative opioids are administered.

PROCEDURE

Opioid-Based Intravenous Anesthesia (OBA-IV)

Standard opioid-based intravenous anesthesia using propofol, remifentanil, and neuromuscular blockade.

PROCEDURE

Opioid-Based Inhalational Anesthesia (OBA-Inh)

Standard opioid-based inhalational anesthesia using sevoflurane, remifentanil, and neuromuscular blockade.

Sponsors & Collaborators

  • Hospital HM Nou Delfos

    lead OTHER

Principal Investigators

  • Gregory Contreras-Pérez, Anesthesiologist · Hospital HM Nou Delfos

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-12-02
Primary Completion
2025-12-02
Completion
2025-12-02

Countries

  • Spain

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06915558 on ClinicalTrials.gov