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Mitochondrial Remodeling After Exercise

NCT04103424 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 31

Last updated 2024-02-13

No results posted yet for this study

Summary

Regulation of mitochondrial health in overweight and obese individuals may be impaired. The purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. The investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.

Conditions

  • Overweight and Obesity
  • Insulin Resistance
  • Metabolic Disease
  • Mitochondrial Metabolism
  • Sedentary Lifestyle

Interventions

BEHAVIORAL

Short-term Exercise Training

Participants will perform 2-weeks of supervised exercise training on a stationary bike.

Sponsors & Collaborators

  • Oregon State University

    lead OTHER

Principal Investigators

  • Sean Newsom, PhD · Oregon State University

  • Matthew Robinson, PhD · Oregon State University

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-08-23
Primary Completion
2020-11-25
Completion
2022-12-03

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04103424 on ClinicalTrials.gov