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Relative Oral Bioavailability of GABA From Tomatoes

NCT04086108 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 12

Last updated 2020-01-21

No results posted yet for this study

Summary

In this four-way crossover study, a plasmakinetic profile of GABA from tomatoes as compared to a gamma-aminobutyric acid (GABA) supplement in healthy young men will be established. In addition, a plasmakinetic profiles of glutamate from a supplement and from tomatoes as well as the effects of glutamate from tomatoes and a supplement on the GABA plasma levels will be determined. This study will therefore provide information about the effect of a food matrix on GABA plasmakinetics.

Conditions

  • GABA Plasmakinetics

Interventions

DIETARY_SUPPLEMENT

Tomato

A maximum of 1 kilo pureed tomatoes, containing 1 gram of GABA.

DIETARY_SUPPLEMENT

GABA supplement

1 gram of GABA dissolved in water.

DIETARY_SUPPLEMENT

Glutamate supplement

A maximum of 8 grams glutamate, adjusted to amount of glutamate given in the tomato arm. Dissolved in water.

Sponsors & Collaborators

  • Nunhems

    collaborator UNKNOWN

  • Agrico Research

    collaborator UNKNOWN

  • Avebe

    collaborator UNKNOWN

  • Wageningen University

    lead OTHER

Principal Investigators

  • Renger Witkamp, PhD · Wageningen University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
28 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-11-04
Primary Completion
2019-12-05
Completion
2019-12-05

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04086108 on ClinicalTrials.gov