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Coronary Microvascular Dysfunction in Chronic Kidney Disease

NCT04014127 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2019-07-10

No results posted yet for this study

Summary

This is an observational study assessing coronary microvascular function in healthy controls with normal kidney function, living kidney donors, pre-dialysis patients with chronic kidney disease stage 5 and patients on peritoneal dialysis.

Conditions

  • Kidney Disease, Chronic
  • Myocardial Dysfunction

Interventions

DIAGNOSTIC_TEST

Coronary flow reserve assessment

Coronary flow reserve will be assessed using Doppler transthoracic echocardiograpy and myocardial contrast echocardiography.

DIAGNOSTIC_TEST

Sphygmocor

Pulse wave analysis and pulse wave velocity will be assessed using the Sphygmocor device

DIAGNOSTIC_TEST

Electrocardiogram

An electrocardiogram will be performed prior to administration of adenosine to ensure no resting conduction disease

OTHER

Blood test

Blood tests will be performed for markers of renal function, bone mineral metabolism and myocardial stretch and injury

OTHER

Urinary albumin/creatinine ratio

Urine will be analysed for albumin/creatinine ratio

Sponsors & Collaborators

  • University Hospital Birmingham NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Jonathan N Townend, MD FRCP FESC · University Hospitals Birmingham

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-05-07
Primary Completion
2020-08-31
Completion
2020-12-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04014127 on ClinicalTrials.gov