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Coronary Microvascular Angina Cardiac Magnetic Resonance Imaging (CorCMR) Trial

NCT04805814 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 280

Last updated 2025-01-30

No results posted yet for this study

Summary

Anginal symptoms due to ischaemia with no obstructive coronary arteries (INOCA) is a common clinical problem, however, diagnosis and onward management is heterogeneous, and prognosis is affected. Recent advances in quantifying myocardial blood flow using stress perfusion cardiac magnetic resonance imaging (CMR) has potential for accurate detection coronary microvascular dysfunction.

The CorCMR diagnostic study involves stress perfusion CMR in patients with suspected INOCA to clarify the prevalence of subgroups of patients with underlying problems, such as microvascular disease or undisclosed obstructive coronary artery disease, that might explain their anginal symptoms.

A nested, prospective, randomised, controlled, double-blind trial will determine whether stratified medical therapy guided by the results of the stress perfusion CMR improves symptoms, well-being, cardiovascular risk and health and economic outcomes.

Conditions

  • Microvascular Angina
  • Angina Pectoris
  • Angina, Stable
  • Non-Obstructive Coronary Atherosclerosis
  • Small Vessel Cerebrovascular Disease
  • Coronary Artery Disease

Interventions

DIAGNOSTIC_TEST

CMR results disclosed

The results of the CMR are disclosed, and used to guide management

DIAGNOSTIC_TEST

CMR performed but results not disclosed

The results of the CMR are not disclosed, and management is angiography-guided

Sponsors & Collaborators

  • University of Glasgow

    collaborator OTHER

  • British Heart Foundation

    collaborator OTHER

  • Chief Scientist Office of the Scottish Government

    collaborator OTHER_GOV

  • NHS National Waiting Times Centre Board

    lead OTHER

Principal Investigators

  • Colin Berry, MBChB, PhD · Univerisity of Glasgow

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-09
Primary Completion
2024-10-01
Completion
2034-10-01

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04805814 on ClinicalTrials.gov