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The DISCOVER INOCA Prospective Multi-center Registry

NCT05288361 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2025-12-18

No results posted yet for this study

Summary

The overall objective of this multi-center registry is to identify specific phenotypes of INOCA with both an anatomic evaluation (coronary angiography and intravascular imaging) and physiologic assessment with the Abbott Coroventis Coroflow Cardiovascular System, and to determine long-term outcomes.

Conditions

  • Ischemia and No Obstructive Coronary Artery Disease
  • Coronary Microvascular Dysfunction
  • Coronary Vasospasm
  • Endothelial Dysfunction
  • Microvascular Angina
  • Chest Pain With Normal Coronary Angiography

Interventions

DIAGNOSTIC_TEST

Coroventis Coroflow Cardiovascular System and PressureWire™ X Guidewire

Patients presenting with symptomatic ischemic heart disease (including chronic stable angina or unstable angina) without evidence of myocardial infarction who require elective or urgent cardiac catheterization, and who meet all eligibility criteria will be enrolled. Participants will undergo routine coronary angiography as well as comprehensive physiologic assessment with intracoronary acetylcholine provocation for diagnosis of vasospastic angina (VSA), coronary thermodilution to evaluate for coronary microvascular dysfunction (CMD), and intracoronary imaging with optical coherence tomography (OCT) or intravascular ultrasound (IVUS) to evaluate for the presence of atheroma, plaque burden, and myocardial bridging.

Sponsors & Collaborators

  • Abbott

    collaborator INDUSTRY

  • Yale University

    lead OTHER

Principal Investigators

  • Samit Shah, MD, PhD · Yale University Medical School

  • Alexandra Lansky, MD · Yale University Medical School

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-09-14
Primary Completion
2032-12-31
Completion
2032-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05288361 on ClinicalTrials.gov