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Coronary Arterial Microcirculation and Metabolism

NCT07074847 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-07-20

No results posted yet for this study

Summary

Coronary microcirculation disorder refers to a disease in which small blood vessels in the coronary arteries are damaged or blocked, leading to myocardial ischemia and hypoxia. This disease usually occurs in patients with coronary heart disease, but it can also occur in other populations. It is caused by abnormal endothelial function of coronary arteries or spasm of small arteries. Its symptoms include chest pain, shortness of breath, palpitations, etc., which usually occur during physical activity or emotional excitement. If left untreated, it may lead to serious consequences such as myocardial infarction.

The methods for treating coronary microcirculation disorders include drug therapy, surgical treatment, and lifestyle changes. Drug therapy includes antiplatelet drugs, lipid-lowering drugs, vasodilators, etc; Surgical treatment includes coronary artery bypass grafting and percutaneous coronary intervention. Lifestyle changes include quitting smoking, weight control, and increasing physical activity. In summary, coronary microcirculation disorders are a disease that leads to myocardial ischemia and require sufficient attention. Early detection and effective treatment measures can prevent the occurrence of complications and improve the quality of life.

If patients with coronary microcirculation disorders can be detected early and treated accordingly, serious consequences can be avoided. Therefore, we plan to investigate the correlation between coronary microcirculation and metabolomics, with the aim of identifying metabolites closely related to coronary microcirculation from the perspective of metabolomics, in order to elucidate the metabolic processes involved in coronary microcirculation disorders.

Conditions

  • Coronary Atherosclerosis of Native Coronary Artery

Interventions

OTHER

Measure QFR

Collect blood samples from 100 patients with normal coronary angiography or stenosis less than 50%, centrifuge and collect plasma, and then send them for further metabolomics testing to analyze the test results.

Sponsors & Collaborators

  • Shaanxi Provincial People's Hospital

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-02-28
Primary Completion
2025-10-30
Completion
2025-12-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07074847 on ClinicalTrials.gov