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Markers of Tissue Injury and Rhabdomyolysis in Patients With Major Trauma

NCT03986736 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 150

Last updated 2024-03-20

No results posted yet for this study

Summary

Major trauma is associated with a release of alarmins (DAMPs - damage-associated molecular patterns) from the injured tissues. This process results in the activation of the immune system, which is one of the main mechanisms participating in the development of organ dysfunctions in patients with major trauma.

Conditions

  • Tissue Injury
  • Major Trauma
  • Rhabdomyolysis

Interventions

DIAGNOSTIC_TEST

Laboratory analysis - upon admission

Laboratory analysis will be performed upon admission of the patient to the hospital. Levels of the following parameters will be determined: HMGB-1, sCK, sMb, serum NGAL, and urine NGAL

DIAGNOSTIC_TEST

Laboratory analysis - 24 hours after injury

Laboratory analysis will be performed upon admission of the patient to the hospital. Levels of the following parameters will be determined: sCK, sMb, serum NGAL, and urine NGAL

Sponsors & Collaborators

  • University Hospital Ostrava

    lead OTHER

Principal Investigators

  • Michal Frelich, MD,PhD · University Hospital Ostrava

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-06-15
Primary Completion
2022-12-31
Completion
2022-12-31

Countries

  • Czechia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03986736 on ClinicalTrials.gov