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Can Biomarkers Aid in the Prediction of Postoperative Pain and Circulatory Instability After Major Abdominal Surgery?

NCT02563652 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 101

Last updated 2018-11-14

No results posted yet for this study

Summary

Patients undergoing major surgery are exposed to extensive damage of tissues, which induces widespread activation of the inflammatory system, called 'systemic inflammatory response syndrome' (SIRS).This activation of the inflammatory system may induce instability of the heart and respiration in the postoperative period. The degree of physiologic response to postoperative SIRS as well as the degree of postoperative pain differ between patients. Therefore, patients undergoing anesthesia and major surgery are treated in a 'post anesthesia care unit' (PACU) after end of surgery.Admittance to a PACU is expensive. The time patients need to stay in a PACU after major surgery has not been extensively studied, and more appropriate tools for prediction of length of stay are needed.

The main aim of this study is to assess whether clinical observations, inflammatory biomarkers or genetic markers may aid in the prediction of physiological instability and/or pain after major surgery. Such predictors would help clinicians planning the length of PACU-stays.

Conditions

  • Systemic Inflammatory Response Syndrome

Sponsors & Collaborators

  • University of Parma

    collaborator OTHER

  • Study in Multidisciplinary Pain Research Group, Italy

    collaborator UNKNOWN

  • Fondazione IRCCS Policlinico San Matteo di Pavia

    collaborator OTHER

  • St. Olavs Hospital

    lead OTHER

Principal Investigators

  • Erik Solligård, phd md · St. Olavs Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-09-30
Primary Completion
2018-09-30
Completion
2018-09-30

Countries

  • Italy
  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02563652 on ClinicalTrials.gov