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Characterization of the Plasma Metallomic Profile to Acute Exercise in Healthy Men and Women (METALEXO)

NCT05718752 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 38

Last updated 2024-06-28

No results posted yet for this study

Summary

Among the various trace elements playing a key role in physical performance, iron is probably one of the most studied in the last 30 years. Iron is an essential component of both hemoglobin and myoglobin allowing an optimal oxygen delivery to organs, especially to skeletal muscle. Iron also plays a major role in the mitochondrial respiratory chain, as well as in the activity of numerous enzymes. Recent studies support the existence of a strong interaction between the iron metabolism and the other non-ferrous trace elements including among others zinc, copper or cobalt. The latter, but also other trace element metals could thus play an important role in physical performance. The finality of this project is thus 1) to determine the variations of plasma iron and non-ferrous metals in response to an acute exercise, 2) better understand the interactions between all these metals, 3) to determine if such responses to exercise are different or not depending on sex.

Conditions

  • Healthy Young Men
  • Healthy Young Women

Interventions

DIAGNOSTIC_TEST

Maximal incremental exercise test

Gas exchange are measured during all the test on ergocycle until oxygen consumption reach its maximum value

DIAGNOSTIC_TEST

30-min submaximal exercise test

A 30-min submaximal test on ergocycle. Gas exchange are measured during all the test. Blood samples are collected before, at the end of exercise and after 3 hours of recovery

Sponsors & Collaborators

  • University of Rennes 2

    lead OTHER

Principal Investigators

  • Frédéric DERBRE, PhD · Laboratory of Movement, Sport and health Sciences (M2S)

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-07
Primary Completion
2024-04-14
Completion
2024-04-14

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05718752 on ClinicalTrials.gov