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The Role of Brain-Bone Marrow-Gut Interaction Following Major Trauma

NCT06606119 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 275

Last updated 2026-02-06

No results posted yet for this study

Summary

Traumatic injury followed by critical illness provokes pathophysiologic changes in the bone marrow and the gut that contribute to persistent anemia and changes in the microbiome which significantly impact long-term recovery. This project will define the interactions between the stress, chronic inflammation, bone marrow dysfunction, and an altered microbiome which will provide a strong foundation for future clinical interventions to help improve outcomes following severe trauma.

Conditions

  • Trauma Injury
  • Trauma
  • Critical Illness
  • Microbiome
  • Chronic Anemia
  • Acute Blood Loss Anemia

Interventions

OTHER

Data and tissue collection

Collection of bone marrow, blood, feces, medical record data, and patient response surveys.

Sponsors & Collaborators

  • National Institutes of Health (NIH)

    collaborator NIH

  • National Institute of General Medical Sciences (NIGMS)

    collaborator NIH

  • University of Florida

    lead OTHER

Principal Investigators

  • Alicia Mohr, MD · University of Florida

Eligibility

Min Age
18 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-01-24
Primary Completion
2027-10-01
Completion
2028-10-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06606119 on ClinicalTrials.gov