Omega-3 Supplementation for LIver VolumE Reduction Study (OLIVER) Study

Summary

Omega-3 has been postulated to reduce hepatic steatosis by reducing lipogenic gene expression, exerting anti- inflammation action, reducing oxidative stress and improving glycemic control.

A recent meta-analysis by Parker et al.\[1\] found that omega-3 supplementation is associated with improvement in liver fat content as well as on Aspartate Aminotransferase (AST) levels. Omega-3 supplementation has also found to be useful in reducing blood triglyceride levels \[2\].

Recent studies by Iannelli et al. (2013) and Abidin et al.(2017) have also found that a 1 month supplementation of 1.5g/day and 2g/day of omega-3 supplementation resulted in reduced hepatic volume of 20% and 34.88 cm3 respectively.

The investigator's hypothesis is that a 4 weeks course of Omega-3 (2 capsules of Blackmores Omega Daily Concentrated Fish Oil per day; Each capsule Concentrated omega-3 triglycerides- fish 1000mg containing Omega-3 Marine Triglycerides 600mg as: 360mg Eicosapentaenoic acid (EPA), 240mg Docosahexaenoic acid (DHA)) taken as supplement, without any other dietary intervention pre Bariatric Surgery decreases significantly liver volume and facilitate access during surgery. And that shrinkage of liver volume also translates to improve biochemical parameters of fatty liver disease

Conditions

• Fatty Liver
• Bariatric Surgery Candidate

Interventions

DIETARY_SUPPLEMENT

2 capsules of Concentrated omega-3 triglycerides- fish 1000mg (600mg Eicosapentaenoic acid (EPA), 1400mg Docosahexaenoic acid (DHA)) per day

4 weeks course of Omega-3 (2 capsules of Blackmores Omega Daily Concentrated Fish Oil per day

Sponsors & Collaborators

• Khoo Teck Puat Hospital

  lead OTHER

Principal Investigators

• Anton Cheng, MBBS FRCS · Khoo Teck Puat Hospital

• Deborah Ng, MBBS MMed · Khoo Teck Puat Hospital

• Tan Chun Hai, MBBS FRCS · Khoo Teck Puat Hospital

• Lim Kheng Tian, MBBS FRCS · Khoo Teck Puat Hospital

• Tan Bo Chuan, MBBS FRCS · Khoo Teck Puat Hospital

• Babu Suresh Balasubramaniam, MBBS FRCR · Khoo Teck Puat Hospital

Study Design

Allocation

NA

Purpose

OTHER

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

21 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-09-17

Primary Completion

2022-12-31

Completion

2023-04-30

Countries

• Singapore

Study Locations