Enhanced Recovery After Surgery (ERAS) in Coronary Artery Bypass Graft / Off Pump Coronary Artery Bypass (CABG/OPCAB)

Summary

It has been assumed that some elements of the ERAS protocol may contribute to the reduction of complications and improve the satisfaction of patients undergoing coronary artery bypass surgery.

Elements of the ERAS strategy will be tested in this study. The elements that prove to be feasible and have a positive effect on the treatment process will be introduced into everyday clinical practice.

In the next stage of the research, we are planning to investigate whether the introduction of the ERAS strategy has had a long-term positive effect on the quality of life after treatment (a survey 1 month and 6 months after leaving the hospital).

Conditions

• Coronary Artery Disease
• Coronary Stenosis

Interventions

BEHAVIORAL

Premedication visit

detailed information about surgery, anaesthesia and postoperative period

DIETARY_SUPPLEMENT

Preoperative period

avoidance of prolonged fasting, intake of fluids with carbohydrates before surgery

DRUG

Preoperative period

administration of melatonin 5 mg in the evening and pregabalin 75 mg one hour before entering the operating theatre

OTHER

Postoperative period

Fluids 1 ml/kg/h; Discontinuation of propofol at the moment of drainage and cardiovascular system stabilization; Fluids administered orally 2 hours after extubation; Early mobilisation

OTHER

Intraoperative period

deep temperature (necessity to maintain normothermia during the stay in the operating theatre 36 °C. Normothermia should be maintained rather than restored.

DRUG

Intraoperative period

Pyralgin 1 g i.v. after induction of anaesthesia; in patients allergic to Pyralginum, Perfalgan 1 g i.v.

DRUG

Intraoperative period

Ketamine 30 mg i.v. after induction of anaesthesia

DRUG

Intraoperative period

Sevoflurane 1.5 MAC higher in patients \< 60 years old

DRUG

Intraoperative period

Propofol infusion in patients at risk of postoperative vomiting (Apfel ≥ 2 points), sevoflurane administration at the moments of strong stimuli from the operating field

DRUG

Intraoperative period

Continuous infusion of balanced multi-electrolyte fluids 1-3 ml/kg/h

Sponsors & Collaborators

• Silesian University of Medicine

  lead OTHER

Principal Investigators

• Ewa Kucewicz-Czech · Upper-Silesian Medical Centre; DEPARTMENT OF ANAESTHESIOLOGY AND INTENSIVE CARE WITH CARDIAC MONITORING

Eligibility

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-05-03

Primary Completion

2020-01-31

Completion

2021-05-31

Countries

• Poland

Study Locations