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Prophylaxis Against Postoperative Atrial Fibrillation in Patients Undergoing On-pump CABG

NCT03905759 · Status: UNKNOWN · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2019-04-05

No results posted yet for this study

Summary

Atrial fibrillation in the postoperative period of myocardial revascularization surgery (AF-POMR) occurs in 10% to 65% of patients, increasing morbidity and mortality after surgery. is associated with an increase in hospital length of stay, and, thus, in costs,and can cause serious clinical complications, such as hypotension, heart failure, stroke and other thromboembolic disorders.Although not completely understood, the electrophysiological mechanism of AF-POMR is believed to be reentry.

Conditions

  • Postoperative Atrial Fibrillation

Interventions

DRUG

Dronedarone

Dronedarone (200 mg twice daily starting from day before operation till 5 days after)

DRUG

Amiodarone

Group A:-amiodarone (200 mg three times per day)21 administered 6 days prior to surgery through 6 days after surgery

DRUG

Colchicine

Colchicine will be used at the dose of 1 mg orally, twice daily, preoperatively (1 days), and of 0.5 mg, twice daily, until hospital discharge

Sponsors & Collaborators

  • doaa rashwan

    lead OTHER

Principal Investigators

  • belal Y Mohammed, Msc · Faculty of Medicine Beni-Suef University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-04-03
Primary Completion
2020-04-10
Completion
2020-04-10

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03905759 on ClinicalTrials.gov