Cell-free Tumor DNA in Head and Neck Cancer Patients

Summary

This study investigates if head and neck squamous cell carcinoma can be tracked with cell-free tumor DNA, RNA or HPV-DNA, in blood samples from patients referred with suspicion of cancer, and if it can be used in detecting recurrence in patients already diagnosed and treated for head and neck squamous cell carcinoma.

Conditions

• Head and Neck Cancer
• Head and Neck Neoplasms
• Head and Neck Squamous Cell Carcinoma
• Oropharynx Cancer
• Oropharynx Neoplasm
• Oropharynx Carcinoma
• Oral Cavity Cancer
• Oral Cancer
• Oral Neoplasm
• Larynx Cancer
• Larynx Carcinoma
• Larynx Neoplasm
• Nasopharyngeal Carcinoma
• Nasopharyngeal Cancer
• Nasopharynx Neoplasm
• Hypopharynx Cancer
• Hypopharynx Neoplasm
• Hypopharynx Carcinoma
• Sinonasal Carcinoma
• Thyroid Carcinoma
• Thyroid Cancer
• Thyroid Neoplasms
• Salivary Gland Cancer
• Salivary Gland Neoplasms
• Salivary Gland Carcinoma
• Sinonasal Cancer
• Sinonasal Neoplasm

Interventions

DIAGNOSTIC_TEST

Liquid biopsy

The intervention is a liquid biopsy as a blood sample taken in a peripheral vein. The blood samples are analyzed for cell free DNA, RNA and HPV-DNA

Sponsors & Collaborators

• Copenhagen University Hospital, Denmark

  collaborator OTHER

• Department of Otorhinolaryngology, Head and Neck Surgery and Audiology

  collaborator UNKNOWN

• Christian von Buchwald

  lead OTHER

Principal Investigators

• Christian Von Buchwald, MD, DMSc · Department of Otorhinolaryngology, Head and Neck Surgery and Audiology

Study Design

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Model

SEQUENTIAL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-02-01

Primary Completion

2025-02-01

Completion

2025-02-01

Countries

• Denmark

Study Locations