MedTrace Logo

Analysis of Patterns of Recurrence in Head and Neck Cancer Using Clinicopathomic Markers

NCT04086849 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 450

Last updated 2023-04-11

No results posted yet for this study

Summary

Here, the investigators will develop a clinicopathomic assay from biomarkers obtained from digital pathologies of resected whole-mount oral cavity and oropharyngeal squamous cell carcinoma (OCSCC and OPSCC) specimens with the goal of administering personalized novel image-guided therapies immediately after primary surgical management in OCSCC and OPSCC patients. The primary aim is to determine the association between clinicopathomic biomarkers and LRR. The secondary aim is to develop a clinicopathomic risk score (assay) such that a decision-support tool can be used by physicians for measuring the benefit of additional therapies (i.e. conventional chemotherapy +/- radiation or administering dose-escalated chemoradiation) in the adjuvant setting to reduce LRR rates.

Conditions

  • Head and Neck Neoplasm
  • Squamous Cell Carcinoma of Head and Neck

Interventions

DIAGNOSTIC_TEST

Radiomic, pathomic, and clinical markers

This is a non-interventional study.

Sponsors & Collaborators

  • Sunnybrook Health Sciences Centre

    lead OTHER

Principal Investigators

  • William Tran, MRT(T), PhD · Sunnybrook Research Institute

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-07-30
Primary Completion
2021-03-26
Completion
2021-04-05

Countries

  • Canada

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04086849 on ClinicalTrials.gov