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Circulating Biomarkers in Oropharyngeal Cancers

NCT05904327 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2023-06-15

No results posted yet for this study

Summary

The goal of this observational longitudinal study is to learn about circulating tumor Human Papilloma Virus-DNA (ctHPV-DNA) as a biomarker for HPV positive oropharyngeal cancer and cancer of unknown primary of the head and neck. The main questions it aims to answer are:

* Can ctHPV-DNA be used for treatment evaluation in HPV positive oropharyngeal cancer and cancer of unknown primary of the head and neck?
* Can circulating HPV-DNA be used as a biomarker for recurrent disease during surveillance?

Participants will be asked to leave plasma samples at diagnose, at the end of treatment and at every clinical follow-up.

The patients are there own controls.

Conditions

  • Oropharynx Squamous Cell Carcinoma
  • Oropharynx Cancer
  • Tonsillar Cancer
  • Base of the Tongue Carcinoma

Sponsors & Collaborators

  • Region Stockholm

    collaborator OTHER_GOV

  • Region Västmanland

    collaborator OTHER

  • Dalarna County Council, Sweden

    collaborator OTHER

  • Sormland County Council, Sweden

    collaborator OTHER

  • Värmland County Council, Sweden

    collaborator OTHER_GOV

  • Region Örebro County

    lead OTHER

Principal Investigators

  • Gisela Helenius · Örebro University, Sweden

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-12-01
Primary Completion
2028-03-31
Completion
2028-03-31

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05904327 on ClinicalTrials.gov