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Study of Treatment's Echocardiographic Mechanisms

NCT03913403 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 210

Last updated 2021-02-10

No results posted yet for this study

Summary

This ancillary study determines whether the Crystalloid Liberal or Vasopressors Early Resuscitation in Sepsis (CLOVERS) \[ClinicalTrials.gov Identifier: NCT03434028\] treatment arms (restrictive fluids strategy vs. liberal fluid strategy) for early sepsis-induced hypotension are associated with differences in cardiac structure and function based on an echocardiogram at 24 hours after randomization. Secondarily, this ancillary study explores possible heterogeneity of treatment effect based on an echocardiogram performed shortly after randomization in CLOVERS.

Conditions

Interventions

PROCEDURE

ECHO

Echocardiogram at baseline and 24 hours later

PROCEDURE

Blood Draw

Blood Draw for Troponin Levels - 5ml at baseline and 24 hours later

Sponsors & Collaborators

  • Beth Israel Deaconess Medical Center

    collaborator OTHER

  • Montefiore Medical Center

    collaborator OTHER

  • Oregon Health and Science University

    collaborator OTHER

  • Vanderbilt University Medical Center

    collaborator OTHER

  • Wake Forest University Health Sciences

    collaborator OTHER

  • Harborview Injury Prevention and Research Center

    collaborator OTHER

  • Intermountain Health Care, Inc.

    lead OTHER

Principal Investigators

  • Samuel Brown, MD · Intermountain Health Care, Inc.

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-04-30
Primary Completion
2021-05-01
Completion
2021-05-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03913403 on ClinicalTrials.gov