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Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock?

NCT02116413 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 145

Last updated 2025-11-19

No results posted yet for this study

Summary

The main objective of this study is to evaluate in a population of patients with septic shock receiving 500 ml crystalloid over 10 minutes, the proportion of patients classified as "responders" to the fluid challenge (increase of at least 15% of ITV in aortic) at the end of vascular filling (T10) and becoming "non-responders" 20 minutes after the end of the fluid challenge (T30) and whether this proportion is greater than 10 points.

Conditions

  • Septic Shock

Interventions

PROCEDURE

Fluid challenge

The fluid challenge starts at minute 0 (T0) and consists of 500ml of crystalloids over 10 minutes.

PROCEDURE

Cardiac ultrasound

Ultrasound measures are made at T0, T2, T4, T6, T8, T10, T20 and T30.

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Nīmes

    lead OTHER

Principal Investigators

  • Claire Roger, MD · Centre Hospitalier Universitaire de Nîmes

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-05-31
Primary Completion
2016-01-08
Completion
2016-01-08

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02116413 on ClinicalTrials.gov