A Longitudinal Cohort Study to Evaluate Cardiovascular Risk Factors and Disease in Haiti

Summary

Investigators will establish a longitudinal cohort of \~3,000 adults \>18 years in Port-au-Prince using multistage random sampling, and follow them longitudinally to evaluate the prevalence and incidence of cardiovascular disease risk factors and diseases. Cardiovascular risk factors include hypertension, diabetes, obesity, dyslipidemia, kidney disease, poor diet, cigarette smoking, physical inactivity, and inflammation. Cardiovascular disease include angina and myocardial infarction, heart failure, stroke, and CVD mortality. It is anticipated that hypertension prevalence will be ≥10% in 18-30 year olds, that hypertension incidence will be \>10 events/1000 person years. Association of determinants and risk factors with CVD will also be examined. Whole blood, serum, plasma, stool, and urine samples will be biobanked for future studies.

Conditions

• Hypertension
• Diabetes
• Obesity
• Kidney Diseases
• Dyslipidemias
• Smoking
• Alcohol Use, Unspecified
• Physical Inactivity
• Poor Diet
• Inflammation
• Myocardial Infarction
• Heart Failure
• Stroke
• Cardiac Death

Interventions

OTHER

Observational Study

No intervention is included in this observational study.

Sponsors & Collaborators

• Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic

  collaborator OTHER

• National Heart, Lung, and Blood Institute (NHLBI)

  collaborator NIH

• Weill Medical College of Cornell University

  lead OTHER

Principal Investigators

• Margaret McNairy, MD, MSc · Washington University School of Medicine

• Jean W Pape, MD · Weill Cornell Medical College /Les Centres GHESKIO

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-03-08

Primary Completion

2028-08-01

Completion

2028-08-01

Countries

• Haiti

Study Locations