Salivary Interactions With Chemosensations

Summary

A counterbalanced, crossover design will be used to evaluate whether exposure to flavors vs. a control over time alters the perception of the flavor by changing an individual's salivary protein profile. Participants will complete 3 acute tasting protocols (baseline, after intervention 1, after intervention 2). The interventions will be with the flavor (epigallocatechin gallate, linolenic acid, capsaicin) or a control, in counterbalanced order, and will involve swishing and swallowing a solution of that sample 5 times per day for two weeks. Each of these flavors will be a separate sub-study.

Conditions

• Diet, Food Choice, Taste

Interventions

OTHER

Epigallocatechin gallate

Colored solution prepared with epigallocatechin gallate to be consumed daily for two weeks during the epigallocatechin gallate intervention.

OTHER

Epigallocatechin gallate control

Colored control solution to be consumed daily for two weeks during the epigallocatechin gallate intervention.

OTHER

Linoleic acid

Colored emulsion prepared with linoleic acid to be consumed daily for two weeks during the linoleic acid intervention.

OTHER

Linoleic acid control

Colored control solution to be consumed daily for two weeks during the linoleic acid intervention.

OTHER

Capsaicin solution

Colored solution prepared with capsaicin to be consumed daily for two weeks during the capsaicin intervention.

OTHER

Capsaicin control

Colored control solution to be consumed daily for two weeks during the capsaicin intervention.

Sponsors & Collaborators

• National Institutes of Health (NIH)

  collaborator NIH

• Purdue University

  lead OTHER

Principal Investigators

• Cordelia Running, PhD · Purdue University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

45 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2019-01-05

Primary Completion

2019-09-24

Completion

2021-12-01

Countries

• United States

Study Locations