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Physiological Flow of Liquids in Healthy Swallowing

NCT04114617 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 80

Last updated 2022-12-21

Study results available
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Summary

Thickened liquids are commonly used as an intervention for people with dysphagia (swallowing impairment). However, the field currently lacks a proper understanding of how this intervention works. The overall goal of the project is to collect measurements of bolus flow through the oropharynx (i.e., mouth and throat) during swallowing. The factors that are expected to influence bolus flow include the liquid/food consistency (i.e., thin, slightly-thick, mildly-thick, moderately-thick, extremely thick, solid) and the forces applied during swallowing (i.e., tongue pressures and swallowing muscle contraction). The objective is to determine how these factors interact to influence the flow of a bolus through the oropharynx in healthy swallowing.

Conditions

  • Deglutition
  • Healthy Swallowing
  • Aging

Interventions

OTHER

Starch-thickened liquids

Thickener added in amounts required to reach slightly thick, mildly thick, moderately thick and extremely thick consistencies, as defined by the International Dysphagia Diet Standardisation Initiative flow test.

OTHER

Xanthan-gum thickened liquids

Thickener added in amounts required to reach slightly thick, mildly thick, moderately thick and extremely thick consistencies, as defined by the International Dysphagia Diet Standardisation Initiative flow test.

COMBINATION_PRODUCT

Barium concentration

Commercially available barium products diluted to different concentrations (i.e., 20% w/v, 40% w/v) through the addition of water

Sponsors & Collaborators

  • National Institute on Deafness and Other Communication Disorders (NIDCD)

    collaborator NIH

  • University Health Network, Toronto

    lead OTHER

Principal Investigators

  • Catriona Steele, PhD · KITE - Toronto Rehabilitation Institute, University Health Network

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-01-01
Primary Completion
2019-09-12
Completion
2020-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04114617 on ClinicalTrials.gov