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Exosomes Implication in PD1-PD-L1 Activation in OSAS

NCT03811600 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2023-02-10

No results posted yet for this study

Summary

An increased occurrence of cancer associated mortality has been described in patients with Obstructive Sleep Apnea Syndrome (OSAS). This association might be partially explained by an impaired cellular immune response that has been described in OSAS. Is has been suggested that OSAS impact immune cells by upregulation of the PD-1/PD-L1 pathway. Exosomes are small membrane vesicles released by numerous cells in the bloodstream. Exosomes have been shown to be implicated in cancer cells proliferation via a PD-1/PD-L1 pathway activation.

This study will evaluate exosomal PD-1/PD-L1 expression in patients with OSAS as compared to controls and will further investigate their impact on immune cells function and proliferation capacities.

Conditions

  • Sleep Apnea Syndromes, Obstructive
  • Cancer

Interventions

DIAGNOSTIC_TEST

PD1/PD-L1 exosomal expression

exosomal PD1/PD-L1 expression

Sponsors & Collaborators

  • University Hospital, Angers

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-03-03
Primary Completion
2020-10-14
Completion
2020-10-14

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03811600 on ClinicalTrials.gov