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Mechanisms of Upper Airway Obstruction

NCT04322097 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 133

Last updated 2026-01-21

Study results available
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Summary

The current study is designed to examine underlying mechanisms of action of lingual muscles in the maintenance of airway patency during sleep. The investigators' major hypothesis is that specific tongue muscles are responsible for relieving upper airway obstruction during sleep.

Conditions

Interventions

DEVICE

Hypoglossal Nerve Stimulation

On/off responses will be assessed both during Drug-Induced Sleep Endoscopy (DISE) and Polysomnography (PSG).

Sponsors & Collaborators

Principal Investigators

  • Raj C Dedhia, MD · University of Pennsylvania

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
22 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-06-03
Primary Completion
2024-05-10
Completion
2024-05-10
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04322097 on ClinicalTrials.gov