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DISE: Phenotyping Obstruction Patterns

NCT05050383 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 241

Last updated 2025-08-13

No results posted yet for this study

Summary

Drug-induced sleep endoscopy (DISE) represents an opportunity to evaluate the upper airway in sleep-like conditions. In its current clinical form, however, DISE does not routinely determine the functional impact of anatomic and neuromuscular factors on airflow obstruction.

The investigators will apply nasal pressure (CPAP) during DISE to generate pressure-flow and pressure-area relationships, deriving functional determinants of upper airway obstruction during sleep. In addition, they will use objective anatomic measurements from computerized tomography (CT) and submental ultrasound. The findings will allow the investigators to streamline the upper airway exam during DISE, and will further the goal of developing personalized solutions that address specific pathogenic mechanisms of pharyngeal collapse and airflow obstruction during sleep.

The investigators will use the physiologic and anatomic features derived from DISE and imaging to determine which are predictive of success to standard-of-care surgical interventions (e.g. skeletal, soft tissue, neurostimulation) .

Conditions

Interventions

OTHER

Pharyngeal Manometry

Catheters will be passed into the nose and advanced to the pharynx to measure airway pressures during drug-induced sleep.

OTHER

Submental Ultrasound

Ultrasound of airway soft tissues

Sponsors & Collaborators

Principal Investigators

  • Raj C Dedhia, MD, MSCR · University of Pennsylvania

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-11-12
Primary Completion
2026-09-30
Completion
2027-09-30

Countries

  • United States

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05050383 on ClinicalTrials.gov