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Using Cumulase for Denudation of Cycles With ≤ 8 Cumulus-oocytes Complexes

NCT03778736 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 586

Last updated 2019-08-07

No results posted yet for this study

Summary

The cumulus-corona-oocyte complex (COCs) surrounds each oocyte and must be removed prior to intracytoplasmic sperm injection (ICSI). This is traditionally achieved with a bovine-derived hyaluronidase followed by mechanical denudation through pipetting. A human recombinant hyaluronidase (Cumulase) has been developed to circumvent the problems and concerns associated with the animal origin and lack of purity of the bovine-derived form of the enzyme. whether cumulase offers a higher chance for success after ICSI for women with 8 COCs or lower remains an open question.

Conditions

Interventions

OTHER

Cumulase denudation

Testing the effect of cumulase for women with poor oocyte yield due to poor ovarian reserve

Sponsors & Collaborators

  • Banoon IVF Center

    collaborator OTHER

  • Quena IVF Center

    collaborator UNKNOWN

  • Ibn Sina Hospital

    lead OTHER_GOV

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-27
Primary Completion
2019-08-01
Completion
2019-08-05

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03778736 on ClinicalTrials.gov